Andrew Stergachis
Assistant Professor
Medical Genetics
Adjunct Assistant Professor
Genome Sciences

Faculty Information

Biography

Dr. Stergachis’ research and clinical practice investigate how alterations in the human genome impact human health and disease. He received his BS in Biochemistry with honors from the University of Chicago, and joined the University of Washington Medical Scientists Training Program (MSTP) in 2007, where he completed his PhD in Genome Sciences. After graduating from the University of Washington Medical School, he completed a combined residency in Internal Medicine and Medical Genetics and Genomics at the Brigham and Women’s Hospital/Harvard Medical School. A Seattle native, Dr Stergachis returned to the Division of Medical Genetics at the University of Washington in 2020.

Education & Training: 
Residency in Medical Genetics and Genomics
Harvard Medical School
Boston, MA
2020
Residency in Internal Medicine
Brigham and Women’s Hospital
Boston, MA
2020
MD
University of Washington
Seattle, WA
2015
Ph.D. in Genome Sciences
University of Washington
Seattle, WA
2013
Honors: 
NIH Director's Early Independence Award
2020
Burroughs Wellcome Career Awards for Medical Scientists
2020
Alpha Omega Alpha
2014
Harold M. Weintraub Graduate Student Award
2014
Charles J. Epstein Award for Excellence in Human Genetics Research
2013
Ruth L. Kirschstein Individual National Research Service Award, NIDDK
2012
Turner Society Endowed Fellowship
2009
Howard Hughes Undergraduate Research Fellowship
2006
Contact
Mailing Address: 

University of Washington

Division of Medical Genetics

1705 NE Pacific St

Box 357720

Seattle, WA 98195-7720

Research & Clinical Interests
Research Interests: 

Our group is motivated by the question of how alterations in gene regulation contribute to human disease. Genomics is rapidly emerging as a cornerstone of medicine, yet our current understanding of the human genome remains largely limited to only 1% of the genome, which is the portion that codes for proteins. By contrast, genetic changes in the other 99% of the human genome that alter when and where proteins are produced remain poorly understood. Our group aims to overcome this challenge by developing and applying novel epigenomic tools to study the impact of non-coding and epigenetic variation on human disease.

Clinical Interests: 

Dr. Stergachis sees patients in the UW Adult Genetics Clinic as well as the UW Cardiovascular Genetics Clinic, and has a broad clinical interest.

Publications
Publications: 

Stergachis, AB., Debo, BM., Haugen, E., Churchman, LS., Stamatoyannopoulos, JA., (2020) Single-molecule regulatory architectures captured by chromatin fiber sequencing, Science, 368, 1449-54

Stergachis, AB., Weiss, ST., Green, RC., (2020) Biobanks could identify medically actionable findings relevant for COVID-19 Clinical Care, Nature Medicine, 26, 991

Stergachis, AB., Mogensen, KM., Khoury, CC., Lin, AP., Peake, RWA., Baker, JJ., Barkoudah, E., Sahai, I., Sweetser, DA., Berry, GT., Krier, JB. (2020) A retrospective study of adult patients with non-cirrhotic hyperammonemia, Journal of Inherited Metabolic Disease, 43, 1165–1172

*Stergachis, AB., *Pujol-Giménez, J., Gyimesi, G., Fuster, D., Albano, G., Troxler, M., Picker, J., Rosenberg, PA., Bergin, A., Peters, J., El Achkar, CM., Harini, C., Manzi, S., Rotenberg, A., Hediger, MA., Rodan, LH. (2019) Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism. Annals of Neurology, 85, 921-926

Li, GZ., Tio, MC., Pak, LM., Krier, J., Tullius, SG., Riella, LV., Malek, SK., Stergachis, AB., (2019) Non-Cirrhotic Hyperammonemia after Deceased Donor Kidney Transplantation: A Case Report. American Journal of Transplantation, 19, 3197–3201

*Stouffs K, *Stergachis AB., Vanderhasselt T, Dica A, Janssens S, Vandervore L, Gheldof A, Bodamer O, Keymolen K, Seneca S, Liebaers I, Jayaraman D, Hill HE, Partlow JN, Walsh CA, Jansen AC. (2018) Expanding the clinical spectrum of biallelic ZNF335 variants. Clin Genet. 94, 246-251

*Stergachis, AB., *Neph, S., Sandstrom, R., Haugen, E., Reynolds, A.P., Zhang, M., Byron, R., Canfield, T., Stelhing-Sun, S., Lee, K., Thurman, R.E., Vong, S., Bates, D., Neri, F., Diegel, M., Giste, E., Dunn, D., Vierstra, J., Hansen, R.S., Johnson, A.K., Sabo, P.J., Wilken, M.S., Reh, T.A., Treuting, P.M., Kaul, R., Groudine, M., Bender, M. A., Borenstein, E. and Stamatoyannopoulos, J. A. (2014) Conservation of trans-acting circuitry during mammalian regulatory evolution. Nature, 515, 365-70

Stergachis, AB., Haugen, E., Shafer, A., Fu, W., Vernot, B., Reynolds, A., Raubitschek, A., Ziegler, A., LeProust, E. M., Akey, J. M., Stamatoyannopoulos, J. A., (2013) Exonic transcription factor binding directs codon choice and affects protein evolution. Science 342, 1367-1372

*Stergachis, AB., *Neph, S., Reynolds, A., Humbert, R., Vernot, B., Miller, B., Thurman, R.E., Sandstrom, R., Haugen, H., Akey, J.M., and Stamatoyannopoulos, J.A. (2013) Developmental fate and cellular maturity encoded in human regulatory DNA landscapes. Cell 154, 888-903

*Neph, S., *Stergachis, AB., Reynolds, A., Sandstrom, R., Borenstein, E., and Stamatoyannopoulos, J. A. (2012). Circuitry and Dynamics of Human Transcription Factor Regulatory Networks. Cell 150, 1274–1286.

*Neph, S., *Vierstra, J., *Stergachis, AB., *Reynolds, A. P., Haugen, E., Vernot, B., Thurman, R. E., John, S., Sandstrom, R., Johnson, A. K., et al. (2012). An expansive human regulatory lexicon encoded in transcription factor footprints. Nature 489, 83–90.

Stergachis, AB., MacLean, B., Lee, K., Stamatoyannopoulos, J. A., and MacCoss, M. J. (2011). Rapid empirical discovery of optimal peptides for targeted proteomics. Nature Methods 8, 1041–1043.