Marianne Dubard-Gault
Assistant Professor
Medical Genetics
Medical Director, Cancer Genetics Program, Seattle Cancer Care Alliance

Faculty Information

Biography

I am the medical director of the Cancer Genetics Program at SCCA. The program features multidisciplinary tumor boards, which bring together experts from a variety of specialties to discuss treatment planning. Through our clinic, patients can receive genetic testing for predisposition to cancers as well as counseling and strategies to help manage increased risk.

My main research interest is to better understand how genetic information influences patients’ decision-making about health care and life choices. I’m also interested in exploring ways to help people better access medical genetic information, talk about it with their families and use that knowledge to make decisions that fit their goals.

Pronouns: She/Her/Hers

Education & Training: 
Undergraduate Degree
Université de Médecine de Lyon
France
Medical Degree
Université de Médecine de Lyon
France
2001-2008
Combined Medicine and Research Residency
Bordeaux School of Public Health, Université de Médecine de Bordeaux
France
Internal Medicine Residency
University of Pennsylvania Health System
Philadelphia, PA
Medical Oncology Fellowship
Hôpital Universitaire de la Réunion
Reunion Island, France
Medical Genetics Fellowship
Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine
New York, NY
Contact
Mailing Address: 

Temporary Mailing Address:

825 Eastlake Avenue E. Box K-231. Seattle WA 98109-1023

 

University of Washington

1705 NE Pacific Street

Box 357720

Seattle, WA 98195

Research & Clinical Interests
Research Interests: 

My main research interest is to better understand how genetic information influences patients’ decision-making about health care and life choices. I’m also interested in exploring ways to help people better access medical genetic information, talk about it with their families and use that knowledge to make decisions that fit their goals.

Clinical Interests: 

My areas of expertise include medical oncology and cancer genetics. Prior to joining SCCA, I completed a fellowship in cancer genetics at Memorial Sloan Kettering Cancer Center in New York. 

Publications
Publications: 

Peer reviewed Journals

Fiala E, Ortiz MV,  Kennedy JA, Glodzik D, Harlan-Fleischut M, Duffy K, Hathaway E, Heaton T,  Ted Gerstle J, Steinherz P, Shukla N, McNeer N, Cadoo K, Carlo M, Latham A, Dubard-Gault ME, Joseph V, Kemel Y, Kentsis A, Stadler Z, LaQuaglia M, Pappaemmanuil E, Friedman D, Ganguly A, Kung A, Offit K, Kalish J, Walsh MF. 11q15.5 Epimutations in Children with Wilms Tumor and Hepatoblastoma. Cancer accepted April 22, 2020

Latham A, Srinivasan P, Kemel Y, Shia J, Bandlamudi C, Mandelker D, Middha S, Hechtman J, Zehir A, Dubard-Gault ME, Tran C, Stewart C, Sheehan M, Penson A, DeLair D, Yaeger R, Vijai J, Mukherjee S, Galle J, Dickson M, Janjigian Y, O’Reilly EM, Segal N, Saltz LB, Reidy Lagunes D, Varghese AM, Bajorin D, Carlo MI, Cadoo K, Walsh MF, Weiser M, Garcia Aguilar J, Klimstra DS, Diaz, Jr. LA, Baselga J, Zhang L, Ladanyi M, Hyman DM, Solit DB, Robson ME, Taylor BS, Offit K, Berger MF, Stadler ZK. Microsatellite Instability Is Associated with the Presence of Lynch Syndrome Pan-Cancer. J Clin Oncol. Accepted Aug 2018.

Dubard-Gault ME, Mandelker M, DeLair D, Stewart C, Kemel Y, Sheehan MR, Siegel B, Kennedy J, Marcell V, Arnold A, Al-Ahmadie H, Modak S, Robson M, Shukla N, Roberts S, Joseph V, Topka S, Kentsis A, Cadoo K, Carlo M, Latham-Schwark A, Reznik E, Dinatale R, Hechtman J, Borras-Flores E, Jairam S, Yang C, Li Y, Bayraktar EC, Ceyhan-Birsoy O, Zhang L, Kohlman W, Schiffman J, Stalder ZK, Birsoy K, Kung A, Offit K and Walsh MF. Germline SDHA mutations in Children and Adults with Cancer. Cold Spring Harbor Molecular Case Studies. Accepted May 2018.

Strickland KC, Krupenko NI, Dubard ME, Hu CJ, Tsybovsky Y, and Krupenko SA: Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase. Chem Biol Interact. 2011 May 30;191(1-3):129-36

Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, and Krupenko SA: ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. J Biol Chem. 2010 Jul 23;285(30):23056-63.

 

Abstracts

Cadoo K, Mukherjee S, Khurram A, Tkachuk K, Lui L, Carlo M, Walsh MF, Levin J, Dubard Gault ME, Mandelker D, Wang A, Salo-Mullen E, Ravichandran V, Stadler Z, Joseph V, Robson M, Seshan O, Offit K: Clinical and Genetic Features of Patients with Multiple Primary Cancers. ASCO Annual meeting, May 2020. Chicago, IL

Dubard Gault ME, Mandelker D, Kemel Y, Vijai J, Latham Schwark A, Carlo M, Cadoo K, Stadler Z, Bayraktar EC, Kung A, Birsoy K, Offit K and Walsh MF: Clinical and metabolic characterization of cancer patients harboring SDHA germline mutations. AACR Cancer and Metabolism chapter, September 2018. Brooklyn, NY

Latham Schwark A, Srinivasan P, Kemel Y, Shia J, Bandlamudi C, Mandelker D, Dubard-Gault ME, Tran C, Middha S, Hechtman J, Penson A, Varghese A, Zhang L, Robson M, Solit D, Diaz L, Taylor B, Offit K, Berger M and Stadler ZK: Pan-cancer Microsatellite Instability Predicts for Presence of Lynch Syndrome. ASCO, Annual meeting, May 2018, Chicago, IL

Dubard-Gault ME, Mandelker D, DeLair D, Kennedy J, Sheehan M, Marcell V, Birsoy O, Al-Ahmadie H, Stewart C, Kemel Y, Joseph V, Cadoo K, Stadler KZ, Carlo M, Modak S, Shukla N, Roberts S, Kung A, Birsoy K, Robson M, Offit K, Walsh MF: Germline SDHA mutations in Adults and Children with Cancers. ACMG, April 2018, Charlotte, NC

Dubard ME and Chirpaz E: A new insight in breast cancer presentation in women under the age of 50 from a retrospective epidemiological study. ASCO Annual Meeting, May 30 - June 3, 2014 in Chicago, IL

Dubard ME, Krupenko NI and Krupenko SA: ALDH1L2ís properties as the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. AACR, April 2010, Washington, DC

Dubard ME, Krupenko NI, and Krupenko SA: ALDH1L2 is the newly discovered mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. FASEB, August 2010, Carefree, AZ

Marianne Dubard, Florence Perret, Herve Michel, et al : Developtment and validation of an organizational culture questionnaire in French Medicine wards.
International Public Health Conference, March 2009, Berlin, Germany