Marshall Horwitz
Adjunct Professor
Medical Genetics
Adjunct Professor
Adjunct Professor
Genome Sciences
Associate Dean, Department of Medicine, University of Washington

Faculty Information

(206) 616-4566

Horwitz, M.S., and Loeb, L.A. (1986) Promoters selected from random DNA sequences. Proc Natl Acad Sci U S A 83, 7405-7409. PMC386726.

Horwitz, M.S., and Loeb, L.A. (1988) An E. coli promoter that regulates transcription by DNA superhelix-induced cruciform extrusion. Science 241, 703-705.

Horwitz, M., Benson, K.F., Person, R.E., Aprikyan, A.G., and Dale, D.C. (1999) Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis. Nat Genet 23, 433-436.

Dale, D.C., Person, R.E., Bolyard, A.A., Aprikyan, A.G., Bos, C., Bonilla, M.A., Boxer, L.A., Kannourakis, G., Zeidler, C., Welte, K., Benson, K.F., and Horwitz, M. (2000) Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. Blood 96, 2317-2322.

Benson, K.F., Li, F.Q., Person, R.E., Albani, D., Duan, Z., Wechsler, J., Meade-White, K., Williams, K., Acland, G.M., Niemeyer, G., Lothrop, C.D., and Horwitz, M. (2003) Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase. Nat Genet 35, 90-96

Person, R.E., Li, F.Q., Duan, Z., Benson, K.F., Wechsler, J., Papadaki, H.A., Eliopoulos, G., Kaufman, C., Bertolone, S.J., Nakamoto, B., Papayannopoulou, T., Grimes, H.L., and Horwitz, M. (2003) Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Nat Genet 34, 308-312. PMC2832179

Salipante, S.J., and Horwitz, M.S. (2006) Phylogenetic fate mapping. Proc Natl Acad Sci U S A 103, 5448-5453. PMC1414797

Salipante, S.J., Mealiffe, M.E., Wechsler, J., Krem, M.M., Liu, Y., Namkoong, S., Bhagat, G., Kirchhoff, T., Offit, K., Lynch, H., Wiernik, P.H., Roshal, M., McMaster, M.L., Tucker, M., Fromm, J.R., Goldin, L.R., and Horwitz, M.S. (2009) Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells. Proc Natl Acad Sci U S A 106, 14920-14925. PMC2736436.

Carmichael, C.L., Wilkins, E.J., Chong, C.-E., Brautigan, P.J., Li, X.-C., Stankovic, M., Lin, M., Carmagnac, A., Butcher, C.M., Friend, K.L, Ekert, P.G., Kok, C.H., Brown, A.L., Lewis, I.D., To, L.B., Timms, A.E., Storek, J., Moore, S., Altree, M., Escher, R., Bardy, P.G., Suthers, G.K., D’Andrea, R.J., Horwitz, M.S., and Scott, H.S. Heritable (2011) GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia. Nat Genet 43, 1012-1017. PMC3184204.

Carlson, C.A., Kas, A., Kirkwood, R., Preston, B.D., Hayes, L.E., Salipante, S.J., and Horwitz, M.S. (2011) Decoding cell lineage from acquired mutations using arbitrary deep sequencing. Nat Methods 9, 78-80.