WendyRaskind
Professor
Medical Genetics
Professor
Psychiatry and Behavioral Sciences
Adjunct Professor
Genome Sciences

Faculty Information

Biography

Pronouns: She/Her/Hers

Education & Training: 
BA Mathematics
Brown University
1964
PhD Genetics
University of Washington
1977
MD
University of Washington
1978
Internship and Residency, Internal Medicine
University of Washington
1978-1981
Fellowship, Medical Genetics
University of Washington
1981-1983
Contact
Email: 
wendyrun@u.washington.edu
Phone: 
(206) 543-3177
Mailing Address: 

University of Washington

Division of Medical Genetics

1705 NE Pacific St

Box 357720

Seattle, WA 98195-7720

Research & Clinical Interests
Research Interests: 

The focus of Dr. Raskind’s research is the study of neurodegenerative and neurobehavioral disorders, both single gene and complex in etiology. A major endeavor is to identify genes involved in mendelian (single-gene) neurologic diseases, including ataxias, movement disorders, and neuopathies. Our approach combines linkage mapping and exome sequencing.The pathogeneses of these diseases are then investigated in cell culture and animal models, with particular attention to the effect of different pathogenic variants on gene function.

The laboratory also has a strong interest in identification of genes responsible for dyslexia. To model and map genetic contributors to dyslexia, multigenerational families were collected and extensively characterized. Quantitative measures used in the clinical assessment of reading disabled children are studied individually and in combination. A recent approach is to evaluate at a genomic level the chromosomal regions detected in the linkage analysis phase.

Clinical Interests: 

Hereditary cancer-risk syndromes

Publications
Publications: 

Allikmets R, Raskind WH, Hutchinson A, Schueck ND, Dean M, Koeller DM: Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A). Hum Molec Genet 8:743-749, 1999.

Yu C, Niakan KK, Matsushita M, Stamatoyannopoulos G, Orkin SH, Raskind WH: X-linked thrombocytopenia with thalassemia due to a mutation in the amino-finger of GATA-1 affecting DNA-binding rather than FOG-1 interaction. Blood 100:2040-2045, 2002.

Chen D-H, Brkanac Z, Verlinde CLMJ, Tan X-J, Bylenok L, Nochlin D, Matsushita M, Lipe H, Wolff J, Fernandez M, Cimino PJ, Bird TD, Raskind WH. Missense mutations in the regulatory domain of PKCg: a new mechanism for dominant nonepisodic cerebellar ataxia. Am J Hum Genet 72:839-849, 2003.

Raskind WH, Igo RP, Jr, Chapman NH, Berninger VW, Thomson JB, Matsushita M, Brkanac Z , Holzman T, Brown M, Wijsman EM. A genome scan in multigenerational families with dyslexia: Identification of a novel locus on chromosome 2q that contributes to phonological decoding efficiency. Molec Psychiatry, 10:699-711, 2005.

Brkanac Z, Spencer D, Shendure J, Robertson PD, Matsushita M, Vu T, Bird TD, Olson MV, Raskind WH. IFRD1 is a candidate gene for SMNA on chromosome 7q22-q23. Am J Hum Genet 84:692-697, 2009.

Korvatska O, Strand NS, Berndt JD, Strovas T, Chen DH, Leverenz JB, Kiianitsa K, Mata IF, Karakoc E, Greenup JL, Bonkowski E, Chuang J, Moon RT, Eichler EE, Nickerson DA, Zabetian CP, Kraemer BC, Bird TD, Raskind WH. Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS). Hum Molec Genet 22:3259-68, 2013.

Chen D-H, Méneret A, Friedman JR, Korvatska O, Gad A, Bonkowski ES, Stessman HA, Doummar D, Mignot C, Anheim M, Bernes S, Davis MY, Damon-Perrière N, Degos B, Grabli D, Gras D, Hisama FM, Mackenzie KM, Swanson PD, Tranchant C, Vidailhet, M, Winesett S, Trouillard O, Amendola LM, Dorschner MO, Weiss M, Eichler EE, Torkamani A, Roze E, Bird TD, Raskind WH. ADCY5-related dyskinesia: broader spectrum and genotype/phenotype correlations. Neurology 85:2026-35, 2015.

Chen DH, Below JE, Shimamura A, Matsushita M, Keel SB, Wolff J, Sul Y, Bonkowski E, Castella M, Taniguchi T, Nickerson D, Papayannopoulou T, Bird TD, Raskind WH. Ataxia-pancytopenia syndrome is caused by missense mutations in SAMD9L. Am J Hum Genet 98:1146-1158, 2016.